New technologies for spatial omics profiling at the cellular level

We are developing new tools at the intersection of microchip, microscopy, genomics, and computational analysis to profile genome, epigenome, transcriptome, and proteome within the spatial context of tissues and cells. These novel technologies will greatly improve our ability to study tissue complexity and reveal the salient features of tissue architecture in physiology and disease.

Exploring complex biological processes in space

It is becoming increasingly recognized that spatial information of cells in the original tissue context is essential for a truly mechanistic understanding of biological processes and disease pathogenesis. Cells proliferate, differentiate, and function while constantly communicating with surrounding cells within tissues. Therefore, cells’ states and developmental landscape are affected by their environment, and specialized cell types and their specific organization are crucially tied to biological activity.